Hippocampal α5 subunit-containing GABAA receptors modulate the expression of prepulse inhibition
نویسندگان
چکیده
منابع مشابه
Hippocampal network hyperactivity following selective reduction of tonic inhibition in GABAA receptor α5 subunit deficient mice
Functionally, GABAA receptor (GABAR)-mediated inhibition can be classified as phasic (synaptic) and tonic (extrasynaptic). The GABARs underlying tonic inhibition assemble from different subunits than those responsible for phasic inhibition. We wanted to assess the excitability of hippocampal pyramidal cell (PC) networks following a selective impairment of tonic inhibition. This is difficult to ...
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Systemic inflammation causes learning and memory deficits through mechanisms that remain poorly understood. Here, we studied the pathogenesis of memory loss associated with inflammation and found that we could reverse memory deficits by pharmacologically inhibiting α5-subunit-containing γ-aminobutyric acid type A (α5GABA(A)) receptors and deleting the gene associated with the α5 subunit. Acute ...
متن کاملStoichiometry of δ subunit containing GABAA receptors
BACKGROUND AND PURPOSE Although the stoichiometry of the major synaptic αβγ subunit-containing GABAA receptors has consensus support for 2α:2β:1γ, a clear view of the stoichiometry of extrasynaptic receptors containing δ subunits has remained elusive. Here we examine the subunit stoichiometry of recombinant α4β3δ receptors using a reporter mutation and a functional electrophysiological approach...
متن کاملLow ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons.
In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by delta subunit-containing GABA(A) receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. In contrast, the tonic inhibition mediated by alpha5 subunit-containing receptors of ...
متن کاملBrief Communication Low Ethanol Concentrations Selectively Augment the Tonic Inhibition Mediated by Subunit-Containing GABAA Receptors in Hippocampal Neurons
In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by subunit-containing GABAA receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. In contrast, the tonic inhibition mediated by 5 subunit-containing receptors of CA1 pyramidal...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2004
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001554